Search results for " s+1"

High-frequency climate fluctuations over the last deglaciation in the Alboran Sea, Western Mediterranean: Evidence from calcareous plankton assemblag…

2018

Abstract A high resolution study, with a centennial scale resolution, has been performed on the calcareous plankton assemblage (coccolithophores and planktonic foraminifera) at Ocean Drilling Program Site 976, Alboran Sea (Western Mediterranean), focusing on the interval between 20 and 9 ka, in order to reconstruct changes in surface and subsurface water dynamics and productivity. The biotic surface water proxies integrate the extremely detailed (multi-decadal scale) geochemical data set and the pollen record already available at the core, thus providing a complete paleoenvironmental/paleoceanographic reconstruction. The results highlight the sensitivity of the calcareous plankton in record…

Novel Insights of Effects of Pregabalin on Neural Mechanisms of Intracortical Disinhibition in Physiopathology of Fibromyalgia: An Explanatory, Rando…

2018

Submitted by DSpace Unilasalle (dspace@unilasalle.edu.br) on 2021-09-14T16:51:25Z No. of bitstreams: 1 adeitos.etal.pdf: 2278622 bytes, checksum: dd96bf75fdbab601238c2831da009c73 (MD5) Made available in DSpace on 2021-09-14T16:51:25Z (GMT). No. of bitstreams: 1 adeitos.etal.pdf: 2278622 bytes, checksum: dd96bf75fdbab601238c2831da009c73 (MD5) Previous issue date: 2018 Background: The fibromyalgia (FM) physiopathology involves an intracortical excitability/inhibition imbalance as measured by transcranial magnetic stimulation measures (TMS). TMS measures provide an index that can help to understand how the basal neuronal plasticity state (i.e., levels of the serum neurotrophins brain-derived n…

Fast Regulation of GABAAR Diffusion Dynamics by Nogo-A Signaling.

2019

Summary: Precisely controlling the excitatory and inhibitory balance is crucial for the stability and information-processing ability of neuronal networks. However, the molecular mechanisms maintaining this balance during ongoing sensory experiences are largely unclear. We show that Nogo-A signaling reciprocally regulates excitatory and inhibitory transmission. Loss of function for Nogo-A signaling through S1PR2 rapidly increases GABAAR diffusion, thereby decreasing their number at synaptic sites and the amplitude of GABAergic mIPSCs at CA3 hippocampal neurons. This increase in GABAAR diffusion rate is correlated with an increase in Ca2+ influx and requires the calcineurin-mediated dephospho…

Proinflammatory and amyloidogenic S100A9 induced by traumatic brain injury in mouse model.

2019

Traumatic brain injury (TBI) represents a significant risk factor for development of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. The S100A9-driven amyloid-neuroinflammatory cascade occurring during primary and secondary TBI events can serve as a mechanistic link between TBI and Alzheimer’s as demonstrated recently in the human brain tissues. Here by using immunohistochemistry in the controlled cortical impact TBI mouse model we have found pro-inflammatory S100A9 in the brain tissues of all mice on the first and third post-TBI days, while 70% of mice did not show any S100A9 presence on seventh post-TBI day similar to controls. This indicates that defensive mechanisms effe…

A multiomics analysis of S100 protein family in breast cancer

2018

The S100 gene family is the largest subfamily of calcium binding proteins of EF-hand type, expressed in tissue and cell-specific manner, acting both as intracellular regulators and extracellular mediators. There is a growing interest in the S100 proteins and their relationships with different cancers because of their involvement in a variety of biological events closely related to tumorigenesis and cancer progression. However, the collective role and the possible coordination of this group of proteins, as well as the functional implications of their expression in breast cancer (BC) is still poorly known. We previously reported a large-scale proteomic investigation performed on BC patients f…

Proteomic detection of S100 proteins in breastcancer tissues

2010

Stable isotopic composition of three foraminifera species in ODP Hole 160-963D

2020

Carbon-rich layers exist at both sides of the Mediterranean Sea sedimentary record and are called sapropels and organic rich layers (ORLs), respectively in the eastern and western basins. They have different levels of organic carbon accumulation and seafloor oxygen deprivation. The most recent sapropel and ORL deposition have a different timing, 10.8-6.1 and 14.5-9.0 ka respectively. Here we investigate oxygen isotopic records of three foraminifera species that occupy different habitats within the Sicily Channel water column since ~ 12.0 ka, thus in the sill between the eastern and western Mediterranean basins. These data are ice volume-corrected, to get information on water masses density …

Age and Cytokine Gene Variants Modulate the Immunogenicity and Protective Effect of SARS-CoV-2 mRNA-Based Vaccination

2023

The introduction of anti-SARS-CoV-2 vaccines in late 2020 substantially changed the pandemic picture, inducing effective protection in the population. However, individual variability was observed with different levels of cellular response and neutralizing antibodies. We report data on the impact of age, gender, and 16 single nucleotide polymorphisms (SNPs) of cytokine genes on the anti-SARS-CoV-2 IgG titers measured 31 and 105 days after administration of the second dose of BNT162b2 vaccine to 122 healthy subjects from the health care staff of the Palermo University Hospital, Italy. The higher titers at 31 days were measured in the younger subjects and in subjects bearing T-positive genotyp…

Determination of pollutants with multixenobiotic -resistance inhibiting properties

1995

Abstract Recent evidence indicates that inherent presence of multixenobiotic resistance (MXR) mechanism represents a general biological defence mechanism for protection of organisms against both endogenous and environmental toxins. In aquatic organisms exposed to polluted waters, this P-170 glycoprotein pump also removes ‘new’ man-made toxic chemicals out of cells. Many chemical agents may alter the function of this fragile mechanism. A new class of compounds, referred to as ‘chemosensitizers’, deserve a top rank among environmentally-hazardous chemicals, since they block this basic natural defence mechanism. The authors measured the concentration of such MXR-inhibiting substances by two me…

Conflicting coccolithophore and geochemical evidence for productivity levels in the Eastern Mediterranean sapropel S1

2011

Abstract The cyclic development of anoxic conditions in the eastern Mediterranean deep sea waters is one of the most fascinating research topics in paleoceanographic studies. In combination with bottom water stagnation, enhanced primary production is a common explanation for the deposition of organic-rich layers (sapropels). This is supported by extensive evidence from both geochemical and micropaleontological studies. The correspondence of recent sapropel layers with peaks of the lower photic zone coccolithophore species Florisphaera profunda has been interpreted as a proxy for the development of a deep chlorophyll maximum (DCM), due to the pycnocline/nutricline shallowing into the lower p…